38. Hoffmann M, Honnen S, Mayatepek E, Wätjen W, Koopman WJ, Bossinger O, Distelmaier F. MICS-1 interacts with mitochondrial ATAD-3 and modulates lifespan in C. elegans. Exp Gerontol. 47(3):270-5 2012 

37. Huber W, Böhler P, Wätjen W, Frank W, Spingler B, Kunz PC. Cytotoxicity of ruthenium(II) piano-stoolcomplexes withimidazole-based PN ligands. Journal of Organometallic Chemistry, 717, 187–194 2012

 36. Wetzel C, Kunz PC, Kassack MU, Hamacher A, Böhler P, Wätjen W, Ott I, Rubbiani R, Spingler B: Gold(I) complexes of water-soluble diphos-type ligands: Synthesis, anticancer activity, apoptosis and thioredoxin reductase inhibition. angenommen bei: Dalton Transactions 40(36):9212-20 2011

35. Noffke AL, Bongartz M, Wätjen W, Böhler P, Spingler B, Kunz PC. Synthesis, X-ray crystal structure and cytotoxicity of a new tetranuclear ruthenium arene complex. Journal of Organometallic Chemistry,  696 (5), 1096–1101. 2011

34. Chovolou Y, Ebada SS, Wätjen W, Proksch P. Identification of angular Naphtopyrones from the Philippine echinoderm Comanthus species as inhibitors of the NF-kappa B signalling pathway. Eur. J. Pharmacology, 657, 26-34, 2011  

33. Brückmann NE, Wahl, M, Reiss GJ, Kohns M, Wätjen W, Kunz PC. Polymer Conjugates of Photoinducible CO Releasing Molecules. Eur. J. Inorg. Chem. 2011, 29, 4571-4577

32. Lüpertz R, Wätjen W, Kahl R, Chovolou Y. Dose- and time-dependent effects of doxorubicin on cytotoxicity, cell cycle and apoptotic cell death in human colon carcinoma cells. Toxicology 271, 115-121, 2010      

31. Shi C, Xu M, Bayer M, Deng Z, Wätjen W, Proksch P, Lin W. Phenolic compounds and their protein kinase inhibition and antioxidation from Chinese Mangrove Plant Languncularia racemosa. Phytochemistry. 71, 435-42, 2010  

30. Wätjen W, Putz, A, Chovolou Y, Kampkötter A, Totzke F, Kubbutat MHG, Proksch P, Konuglukil B. Hexa-, Hepta- and Nonaprenylhydroquinone isolated from Marine Sponges Sarcotragus muscarum and Ircinia fasciculata inhibit NF-kB signalling in H4IIE cells. Journal of Pharmacy and Pharmacology, 61, 919-924, 2009     

29. Wätjen W, Debbab A, Hohlfeld A, Chovolou C, Kampkötter A, Edrada RA, Ebel R, Hakiki A, Mosaddak M, Totzke F, Kubbutat MHG, Proksch P. Enniatins A1, B and B1 from an endophytic strain of Fusarium tricinctum induce apoptotic cell death in H4IIE hepatoma cells accompanied by inhibition of ERK phosphorylation, Molecular Nutrition and Food Research, 53, 431-440, 2009     

28. Kampkötter A, Chovolou C, Kulawik A, Röhrdanz E, Weber N, Proksch P, Wätjen W. Isoflavone daidzein possess no antioxidant activities in cell free assays, but induces the antioxidant enzyme catalase. Nutrition Research, 28, 620-628, 2008  

27. Lüpertz R, Chovolou Y, Unfried K, Kampkötter A, Wätjen W, Kahl R. The forkhead transcription factor FOXO4 sensitizes cancer cells to doxorubicin mediated cytotoxicity. Carcinogenesis, 29, 2045-2052, 2008   

26. Wätjen W, Suckow-Schnitker AK, Rohrig R, Kulawik A, Addae-Kyereme J, Wright CW, Passreiter CM. Addisoniaflavanon III: A pro-apoptotic compound isolated from the bark of Erythrina addisoniae. Journal of Natural Products, 71, 735-738, 2008     

25. Kampkötter A, Timpel C, Zurawski R, Ruhl S, Chovolou Y, Proksch P, Wätjen W. Increase of stress resistance and lifespan of Caenorhabditis elegans by quercetin. Comp Biochem Physiol B Biochem Mol Biol. 149, 314-323, 2008 

24. Lüpertz R, Chovolou Y, Kampkötter A, Wätjen W, Kahl R. Catalase overexpression impairs TNF-alpha induced NF-kappaB activation and sensitizes MCF-7 cells against TNF-alpha. J Cell Biochem., 103(5):1497-511, 2008  

23. Kampkötter A, Wiegand C, Timpel C, Röhrdanz E, Chovolou C, Kahl R, Wätjen W. Increased expression of catalase in human hepatoma cells by the soy isoflavone, daidzein. Basic & Clinical Pharmacology & Toxicology, 102, 437-442, 2008   

22. Wätjen W, Kulawik A, Suckow-Schnitker AK, Rohrig R, Ruhl R, Chovolou C, Kampkötter A, Addae-Kyereme J, Wright CW, Passreiter CM*. Pterocarpans phaseollin and neorautenol isolated from Erythrina addisoniae induce apoptotic cell death accompoined by inhibition of ERK phosphorylation. Toxicology, 242(1-3):71-79, 2007   

21. Kampkötter A, Nkwonkam CG, Zurawski RF, Timpel C, Chovolou Y, Wätjen W, Kahl R. Effects of the flavonoids kaempferol and fisetin on thermotolerance, oxidative stress and FoxO transcription factor DAF-16 in the model organism Caenorhabditis elegans. Archives of Toxicology, 81, 849-858, 2007

20. Wätjen W, Weber N, Lou Y-j, Wang Z-q, Chovolou Y, Kampkötter A, Proksch P, Kahl R. Prenylation enhances cytotoxicity of apigenin and liquiritigenin in rat H4IIE hepatoma and C6 glioma cells. Food and Chemical Toxicology, 45, 119-124, 2007        

19. Kampkötter A, Pielarski T, Rohrig R, Timpel C, Chovolou Y, Wätjen W, Kahl R. The Ginkgo biloba extract Egb761 reduces stress sensitivity, ROS accumulation and expression of catalase and glutathione S-transferase 4 in Caenorhabditis elegans. Pharmacological Research, 55, 139-147, 2007   

18. Chovolou Y, Wätjen W, Kampkötter A, Kahl R. Downregulation of NF-kappaB activation in a H4IIE transfectant insensitive to doxorubicin-induced apoptosis. Toxicology, 232, 89-98, 2007   

17. Kampkötter A, Nkwonkam CG, Zurawski RF, Timpel C, Chovolou Y, Wätjen W, Kahl R. Investigations of protective effects of the flavonoids quercetin and rutin on stress resistance in the model organism Caenorhabditis elegans. Toxicology, 234, 113-123, 2007   

16. Ashour M, Edrada R, Ebel R, Wray V, Wätjen W, Padmakumar K, Müller WEG, Lin WH, Proksch P. New Kahalalide Derivatives from the Indian Sacoglossan Mollusc Elysia grandifolia. Journal of Natural Products, 69, 1547-1553, 2006   

15. Michels G, Wätjen W, Weber N., Niering P, Chovolou Y, Kampkötter A, Proksch P, Kahl R. Resveratrol induces apoptotic cell death in rat H4IIE hepatoma cells but necrosis in C6 glioma cells. Toxicology, 225, 173-182, 2006   

14. Michels G, Mohamed G, Weber N, Chovolou Y, Kampkötter A, Wätjen W, Proksch P. Effects of methylated derivates of luteolin isolated from Cyperus alopecuroides in rat H4IIE hepatoma cells. Basic & Clinical Pharmacology & Toxicology, 98, 168-172, 2006    

13. Niering P, Michels G, Wätjen W, Ohler S, Steffan B, Chovolou Y, Kampkötter A, Proksch P, Kahl R. Protective and detrimental effects of kaempferol in rat H4IIE cells: Implication of oxidative stress and apoptosis. Toxicology and Applied Pharmacology, 209, 114-122, 2005   

12. Michels G, Wätjen W, Niering P, Steffan B, Tran-Thi Q-H. Chovolou Y, Kampkötter A, Bast A, Proksch P, Kahl R. Pro-apoptotic effects of the flavonoid luteolin in rat H4IIE cells. Toxicology, 206, 337-348, 2005   

11. Steffan B, Wätjen W, Michels G, Niering P, Wray V, Ebel R, Edrada-Ebel R, Kahl R, Proksch P. Polyphenols from plants used in traditional Indonesian medicine (Jamu) - uptake and antioxidative effects in rat H4IIE hepatoma cells. Journal of Pharmacy and Pharmacology, 57, 233-240, 2005   

10. Wätjen W, Michels G, Steffan B, Niering P, Chovolou Y, Kampkötter A, Tran-Thi Q-H, Proksch P, Kahl R. Low concentrations of flavonoids are protective in rat H4IIE cells whereas high concentrations cause DNA damage and apoptosis. Journal of Nutrition, 135, 525-531, 2005   

9. Di Virgilio AL, Iwami K, Wätjen W, Kahl R, Degen GH. Genotoxicity of the isoflavones genistein, daidzein and equol in V79 cells. Toxicology Letters, 151, 151-162, 2004   

8. Wätjen W, Beyersmann D. Cadmium induces apoptosis in C6 glioma cells: influence of oxidative stress. Biometals, 17, 65-78, 2004  

7. Michels G, Haenen GR, Wätjen W, Rietjens S, Bast A. The thiol reactivity of the oxidation product of 3,5,7-trihydroxy-4H-chromen-4-one containing flavonoids. Toxicology Letters, 151, 105-111, 2004   

6. Chovolou Y, Wätjen W, Kampkötter A, Kahl R. Resistance to TNF-a induced apoptosis in rat hepatoma cells expressing TNF-a is linked to low antioxidant expression. Journal of Biological Chemistry, 278, 29626-29632, 2003   

5. Wätjen W, Biagioli M, Cox M, Beyersmann D. Cadmium induces apoptosis in C6 glioma cells mediated by caspase 9-activation. Biometals, 15, 15-25, 2002  

4. Wätjen W, Haase H, Biagioli M, Beyersmann D. Induction of apoptosis in mammalian cells by cadmium and zinc. Environmental Health Perspectives, 110 (Suppl. 5), 865-867, 2002   

3. Biagioli M, Wätjen W, Beyersmann D, Zoncu R, Cappellini C, Ragghianti M, Cremisi F, Bucci S. Cadmium induced apoptosis in murine fibroblasts is suppressed by Bcl-2. Archives of Toxicology, 75, 313-320, 2001   

2. Haase H, Wätjen W, Beyersmann D. Zinc induces apoptosis that can be suppressed by lanthanum in C6 rat glioma cells. Biological Chemistry, 382, 1227-1234, 2001   

1. Wätjen W, Benters J, Haase H, Schwede F, Jastorff B, Beyersmann D. Zn2+ and Cd2+ increase the cyclic GMP level in PC12 cells by inhibition of the cyclic nucleotide phosphodiesterase. Toxicology, 157, 167-175, 2001   



 4.. Wätjen W, Fritsche E. Rolle des Fremdstoffmetabolismus in Pharmakologie und Toxikologie: Teil 2: Phase-II-Reaktionen, Apotheken-Magazin 9, 6-13, 2010

3. Wätjen W, Fritsche E. Rolle des Fremdstoffmetabolismus in Pharmakologie und Toxikologie: Teil 1: Phase-I-Reaktionen, Apotheken-Magazin 5, 8-14, 2009

2. Passreiter C, Wätjen W. Hexenkräuter, Hexenmedizin. Apotheken-Magazin 5, 8-14, 2007

1. Kahl R, Kampkötter A, Wätjen W, Chovolou Y. Antioxidant enzymes and apoptosis. Drug Metabolism Reviews, 36, 747-762, 2004  


eingereichte Arbeiten

Hamed ANES, Wätjen W, Schmitz R, Chovolou Y, Edrada-Ebel RA, Youssef DTA, Salah Kamel M, Proksch P. A New Bioactive Sesquiterpenoid Quinone from the Mediterranean Sea Marine Sponge Dysidea avara eingereicht bei: “Natural Product Communications“

Havermann S, Rohrig R, Chovolou Y, Humpf HU, Wätjen W. Molecular Effects of Baicalein in Hct116 Cells and Caenorhabditis elegans: Activation of the Nrf2 Signalling Pathway and Prolongation of Lifespan.eingereicht bei: “Journal of Agricultural and Food Chemistry”



10. Kahl R, Wätjen W. Morphologie und Funktion der Leber. In: Marquardt H, Schäfer SG und Barth H (Herausgeber) Toxikologie, 3. Auflage, Erscheinungstermin: 2013

9. Wätjen W, Fritsche E. Fremdstoff-Metabolismus. In: HW Vohr (Herausgeber): Toxikologie (Band I: Grundlagen der Toxikologie), Wiley-VCH-Verlag ISBN: 978-3527-32319-7, 2010

8. Wätjen W, Chovolou Y, Bolt HM, Toxikologie von Gasen. In: HW Vohr (Herausgeber): Toxikologie (Band II: Toxikologie der Stoffe), Wiley-VCH-Verlag ISBN: 978-3527-32385-2, 2010

7. Kahl R, Wätjen W. Liver injury in man ascribed to non-drug chemicals and natural toxins. In: Textbook of Hepatology: From Basic Science to Clinical Practice (Editors: Rodes, Benhamou, Blei, Reichen, Rizzetto), Blackwell Publishing; 3rd edition, ISBN: 978-1-4051-2741-7, page 2105-2121, 2007

6. Wätjen W, Chovolou Y, Kampkötter A, Kahl R. Antiapoptotic and proapoptotic effects of polyphenols. In: New Cell Apoptosis Research (Editor: L.C. Vinter), Nova Science Publishers, Inc. N.Y. ISBN: 1-60021-430-4, 2006

5. Wätjen W, Chovolou Y, Kampkötter A, Kahl R. Anti- and prooxidative effects of flavonoids, in: Leading Edge Antioxidant Research (Editor: H.V. Panglossi), Nova Science Publishers, Inc. N.Y. ISBN: 1-60021-274-3, 2006

4. Wätjen W, Chovolou Y, Niering P, Kampkötter A, Tran-Thi Q-H, Kahl R. Pro- and antiapoptotic effects of flavonoids in H4IIE cells: implication of oxidative stress. DFG-Symposium “Functional Food: Safety Aspects”, Senate Commission on Food Safety, VCH-Wiley, 338-344, 2004

3. Kampkötter A, Röhrdanz E, Iwami K, Ohler S, Wätjen W, Chovolou Y, Kulling S, Kahl R. Influence of daidzein and its metabolites on the expression of catalase in rat hepatoma cells. DFG-Symposium “Functional Food: Safety Aspects”, Senate Commission on Food Safety, VCH-Wiley, 293-298, 2004

2. Niering P, Wätjen W, Ohler S, Köhler I, Chovolou Y, Kampkötter A, Tran-Thi Q-H, Kahl R. Investigation of Oxidative Stress in H4IIE Cells: Modulation by the Flavonoid Kaempferol. DFG-Symposium “Functional Food: Safety Aspects”, Senate Commission on Food Safety, VCH-Wiley, 319-325, 2004

1. Wätjen W. Cadmium-induzierte Apoptose in Säugerzellen: Einfluss von intrazellulärer Signaltransduktion und oxidativem Stress. GCA-Verlag; ISBN 3-89863-064-1, 2001